Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans 1 The nucleotide sequences of human OGFr have been deposited in GenBank under accession numbers AF172449, AF172450, AF172451, AF172452, and AF172453. 1

@article{Zagon2000CloningSC,
  title={Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans
 1
 The nucleotide sequences of human OGFr have been deposited in GenBank under accession numbers AF172449, AF172450, AF172451, AF172452, and AF172453.
 
 
 1
 
},
  author={Ian S. Zagon and Michael F Verderame and Sandra S Allen and Patricia J. McLaughlin},
  journal={Brain Research},
  year={2000},
  volume={856},
  pages={75-83}
}
The native opioid growth factor (OGF), [Met(5)]-enkephalin, is a tonic inhibitory peptide that modulates cell proliferation and tissue organization during development, cancer, cellular renewal, wound healing, and angiogenesis. OGF action is mediated by a receptor mechanism. We have cloned and sequenced cDNAs encoding multiple spliced forms of a human OGF receptor. The open reading frame in the longest cDNA was found to encode a protein of 697 amino acids, and 8 imperfect repeats of 20 amino… 
Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse.
TLDR
The results emphasize the molecular validity of OGFr, and explain the interaction of OGF with respect to normal and abnormal growth in mouse cells and tissues.
An opioid growth factor receptor (OGFR) for [Met5]-enkephalin in Chlamys farreri.
TLDR
Results collectively indicated that CfOGFR, as a homolog of OGFRs in C. farreri, played an important role in cells proliferation, and might be involved in the immune response of scallops.
The biology of the opioid growth factor receptor (OGFr)
TLDR
The history of OGF-OGFr is reviewed, emerging insights into the mechanisms of action of opioid peptide-receptor interfacing are examined, and clinical significance of these observations are discussed.
Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin β and Ran for nucleocytoplasmic trafficking
TLDR
The results indicate that the regulation of cell proliferation by the OGF–OGFr axis is dependent on nucleocytoplasmic transport by karyopherin β1 as well as the gradient of RanGTP/RanGDP across the nuclear envelope, but is not reliant on adaptor molecules related to kARYopherin α.
The opioid growth factor-opioid growth factor receptor axis: homeostatic regulator of cell proliferation and its implications for health and disease.
TLDR
Understanding the OGF-OGFr axis as a homeostatic regulator of proliferation has substantial implications for maintaining human health and treatment of disease.
Gene expression of OGFr in the developing and adult rat brain and cerebellum
TLDR
Gene expression of OGFr in the developing and adult brain and cerebellum of the rat is investigated using Northern blot analysis and normalization to GAPDH to show that message for OGFr is developmentally regulated prior to and after birth, is ubiquitously expressed during development, and is present in the adult Brain and Cerebellum even though OGF receptor binding is not recorded.
Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor.
TLDR
Data support OGFr gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer.
Targeting the opioid growth factor: Opioid growth factor receptor axis for treatment of human ovarian cancer
TLDR
Preclinical data support the transition of these novel therapies for treatment of human ovarian cancer from the bench to bedside to provide additional targets for treatment for this devastating disease.
MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients.
TLDR
Using sera from a long-term surviving metastatic melanoma patient vaccinated with irradiated, autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF), an antigen reported to be a putative opioid growth factor receptor (OGFr) was identified and antibody responses to OGFr and a synthetic peptide representing aPutative alternative reading frame product (OG Fr-ARF) were frequently found in cancer patients.
Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue.
TLDR
This is the first study showing OGFR and OGFRL1 are androgen repressed genes, and these results suggest a role for the opioid signaling axis in prostate cancer.
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References

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Cloning, sequencing, expression and function of a cDNA encoding a receptor for the opioid growth factor, [Met5]enkephalin 1 The nucleotide sequence of the rat OGFr has been deposited in GenBank under accession number AF 156878. 1
TLDR
The cloned and sequenced a 2.1-kilobase cDNA for a receptor to OGF (OGFr) exhibited the pharmacological, temporal and spatial characteristics of the OGFr, and molecular validity for the interaction of OGF and OGFr in the regulation of growth processes is provided.
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TLDR
A random primed expression cDNA library was constructed from the RNA of NG 108-15 cells that encodes a 371-amino acid-residue protein presenting all the structural characteristics of receptors that interact with guanine nucleotide-binding proteins.
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TLDR
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TLDR
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TLDR
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  • K. Yasuda, K. Raynor, +4 authors G. Bell
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
TLDR
RNA blotting studies and in situ hybridization histochemistry showed that kappa opioid receptor mRNA was expressed at high levels in brain in the neocortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus, suggesting that this receptor may play a role in arousal and regulation of autonomic and neuroendocrine functions.
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