Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand.

@article{Xu2000CloningSA,
  title={Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand.},
  author={Jiake Xu and Jamie We-Yin Tan and Leeyuan Huang and Xiu Hui Gao and Rebecca Laird and Dawei Liu and Stan Wysocki and Ming H. Zheng},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2000},
  volume={15 11},
  pages={2178-86}
}
A complementary DNA (cDNA) encoding the rat homologue of receptor activator of NF-kappaB ligand/osteoprotegerin ligand/osteoclast differentiation factor/tumor necrosis factor (TNF)-related activation-induced cytokine (RANKL/OPGL/ODF/TRANCE) was cloned and sequenced from tibias of ovariectomized (OVX) rats. The predicted amino acid sequence of rat RANKL (rRANKL) has 84% and 96% identity to that of human and mouse RANKL, respectively, and 35% and 37% similarity to that of human and mouse TNF… CONTINUE READING
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