Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA.

@article{Lee1995CloningSA,
  title={Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA.},
  author={Francesca K M Lee and Alice S Y Lee and Cindy Q X Lin and Sung Soo Chung and Sookja K Chung},
  journal={European journal of biochemistry},
  year={1995},
  volume={230 3},
  pages={1059-65}
}
Sorbitol dehydrogenase is one of the enzymes in the polyol pathway, which is thought to be implicated in the pathogenesis of diabetic complications. The cDNA encoding mouse sorbitol dehydrogenase was cloned from a liver library and its sequence was determined. The open reading frame encodes a product of 356 amino acids that shares high similarity with the human and rat liver sorbitol dehydrogenases (83% and 93% identity, respectively). The 3'-untranslated region contains a truncated L1Md repeat… CONTINUE READING