Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

@article{March1985CloningSA,
  title={Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs},
  author={C. March and Bruce Mosley and A. Larsen and Douglas Pat Cerretti and G. Braedt and V. Price and S. Gillis and Christopher S. Henney and Shirley R. Kronheim and K. Grabstein and Paul J. Conlon and T. Hopp and D. Cosman},
  journal={Nature},
  year={1985},
  volume={315},
  pages={641-647}
}
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity. 
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