Cloning, sequence analysis and expression of ovine CD154 (CD40 ligand).

  title={Cloning, sequence analysis and expression of ovine CD154 (CD40 ligand).},
  author={Gabriela Olędzka and Bo Li and Graham William Kay and Lidia Chomicz and Miroslaw Stankiewicz},
  journal={Molecular immunology},
  volume={44 5},
The CD154 (CD40 ligand) molecule is a member of the tumor necrosis factor (TNF) family and plays an important role in the interaction between antigen-specific lymphocytes and antigen-presenting cells. In this study, reverse transcription-PCR cloning was used to derive the sequence encoding ovine CD154. Sequence analysis of the cloned CD154 gene showed a similarity of 97%, 89%, and 88% with the bovine, porcine and human sequences, respectively, at the nucleic acid level. The deduced amino acid… CONTINUE READING

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