Cloning, purification and characterization of non-human primate 12/15-lipoxygenases.

  title={Cloning, purification and characterization of non-human primate 12/15-lipoxygenases.},
  author={Malin Johannesson and Linda Backman and H-E Claesson and Pontus K. A. Forsell},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  volume={82 2-3},
The enzyme 15-lipoxygenase-1 (15-LO-1) possesses mainly 15-LO activity and has so far only been described in human cells and rabbit reticulocytes. The animal ortholog, except rabbit reticulocytes, is an enzyme with predominantly a 12-lipoxygenase activity, commonly referred to as 12/15-LO. We describe herein the characterization of the 12/15-LOs in Macaca mulatta (rhesus monkey) and in Pongo pygmaeus (orang-utan). The rhesus and the orang-utan enzymes have mainly 12-lipoxygenase and 15… CONTINUE READING