Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).

@article{Dolphin1991CloningPS,
  title={Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).},
  author={Colin T. Dolphin and Elizabeth A Shephard and Sue Povey and Colin N A Palmer and Daniel M. Ziegler and Riad Ayesh and R L Smith and Ian R. Phillips},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 19},
  pages={12379-85}
}
cDNA clones that code for a pig and human flavin-containing monooxygenase (FMO) have been isolated. The full-length sequence of the human cDNAs revealed that they encode a polypeptide of 532 amino acid residues containing putative FAD- and NADP-binding sites. The deduced amino acid sequence has 88 and 86% identity, respectively, with the pig and rabbit "hepatic" forms of FMO, but is only 58% similar to the rabbit "pulmonary" FMO, and thus represents the human ortholog of the "hepatic" form of… CONTINUE READING

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