Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

  title={Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.},
  author={Bruno Giros and Salah El Mestikawy and Nathalie Godinot and Ke-qin Zheng and Hong Peng Han and Teresa L. Yang-Feng and Marc G. Caron},
  journal={Molecular pharmacology},
  volume={42 3},
We have screened a human substantia nigra cDNA library with probes derived from the rat dopamine transporter. A 3.5-kilobase cDNA clone was isolated and its corresponding gene was located on the distal end of chromosome 5 (5p15.3). This human clone codes for a 620-amino acid protein with a calculated molecular weight of 68,517. Hydropathicity analysis suggests the presence of 12 putative transmembrane domains, a characteristic feature of sodium-dependent neurotransmitter carriers. The rat and… CONTINUE READING
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