Cloning, localization and focus formation at DNA damage sites of canine Ku70

@inproceedings{Koike2017CloningLA,
  title={Cloning, localization and focus formation at DNA damage sites of canine Ku70},
  author={Manabu Koike and Yasutomo Yutoku and Aki Koike},
  booktitle={The Journal of veterinary medical science},
  year={2017}
}
Understanding the molecular mechanisms of DNA double-strand break (DSB) repair machinery, specifically non-homologous DNA-end joining (NHEJ), is crucial for developing next-generation radiotherapies and common chemotherapeutics for human and animal cancers. The localization, protein-protein interactions and post-translational modifications of core NHEJ factors, might play vital roles for regulation of NHEJ activity. The human Ku heterodimer (Ku70/Ku80) is a core NHEJ factor in the NHEJ pathway… CONTINUE READING
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