Cloning, localization, and permanent expression of a Drosophila octopamine receptor.

  title={Cloning, localization, and permanent expression of a Drosophila octopamine receptor.},
  author={Seiji Arakawa and Jeannine D. Gocayne and W. Richard McCombie and David Urquhart and L. M. Hall and Claire M. Fraser and J. C. Venter},
  volume={4 3},
A cDNA for a member of the G protein-coupled receptor family was isolated from Drosophila using a probe derived from a human beta 2-adrenergic receptor cDNA. This Drosophila receptor gene is localized at 99A10-B1 on the right arm of chromosome 3 and is preferentially expressed in Drosophila heads. The insect octopamine receptor has been permanently expressed in mammalian cells, where it mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile consistent with… CONTINUE READING
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