Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate.

@article{Birnbaum2005CloningIA,
  title={Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate.},
  author={Andrea D. Birnbaum and Susan K Rohde and Haohua Qian and Muayyad R. Al-Ubaidi and John H. Caldwell and Robert Paul Malchow},
  journal={Visual neuroscience},
  year={2005},
  volume={22 2},
  pages={211-23}
}
Termination of GABA signals within the retina occurs through high-affinity reuptake of the released neurotransmitter by GABA transporters (GATs) present in neurons and glia surrounding the release site. In the present work, we have cloned a novel GAT from the retina of the skate (Raja erinacea). The clone codes for a 622 amino acid protein whose sequence has highest similarity to the GABA/beta-alanine transporter of the electric ray (Torpedo marmorata) (88% identity) and the GAT-3 isolated from… CONTINUE READING
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~1994a!. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1

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