Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants.

@article{Hirasawa1995CloningFE,
  title={Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants.},
  author={Akira Hirasawa and Kazuhiro Shibata and Kaeko Horie and Yoshio Takei and K Obika and Toshio Tanaka and Nobuhiko Muramoto and Kazuchika Takagaki and Junichi Yano and Gozoh Tsujimoto},
  journal={FEBS letters},
  year={1995},
  volume={363 3},
  pages={256-60}
}
We report the cloning and characterization of two isoforms of human alpha 1c-adrenoceptor cDNA (alpha 1c-2, alpha 1c-3). These isoforms are generated by alternative splicing and differ from the clone we previously isolated (alpha 1c-1) in their length and sequences of the C-terminal domain. Tissue distribution of mRNAs showed that these variants co-express with alpha 1c-1 in the human heart, liver, cerebellum and cerebrum. Despite the structural differences, functional experiments in… CONTINUE READING

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