Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

@article{Albert1990CloningFE,
  title={Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.},
  author={Paul R Albert and Qun Yong Zhou and Hubert H M Van Tol and James R. Bunzow and Olivier Civelli},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 10},
  pages={5825-32}
}
G protein-coupled receptors comprise a family of genes that share significant sequence similarity. We have screened a rat genomic library under low stringency hybridization conditions with the coding portion of the hamster beta 2-adrenergic receptor gene to isolate new members of this gene family. We show that one of these clones, clone D, codes for a 5-hydroxytryptamine1A (5-HT1A) binding site since: 1) it possesses an intronless open reading frame encoding a protein with seven putative… CONTINUE READING
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