Cloning, expression and characterization of human glutathione S-transferase Omega 2.

  title={Cloning, expression and characterization of human glutathione S-transferase Omega 2.},
  author={Liu Wang and Jian Xu and Chaoneng Ji and Shao-hua Gu and You Lv and Shi Li and Yiren Xu and Yi Xie and Yu-min Mao},
  journal={International journal of molecular medicine},
  volume={16 1},
  • Liu WangJian Xu Y. Mao
  • Published 1 July 2005
  • Biology
  • International journal of molecular medicine
The class of Omega glutathione transferases is newly identified with novel structural and functional characteristics. Human GSTO 1-1 (glutathione S-transferase Omega 1) is the first member of the GST Omega class. It was found to play a role in apoptosis and be in association with age-at-onset of AD and PD. In order to improve the understanding of the properties of other Omega class members, we screened a human fetal brain cDNA library and obtained the human GSTO2 (glutathione S-transferase… 

The omega-class glutathione transferases: structure, function, and genetics

  • P. Board
  • Biology
    Drug metabolism reviews
  • 2011
The omega class of glutathione transferases (GSTs) is a relatively ancient member of the cytosolic GST superfamily, and the omega-class GSTs are found in plants, animals, and some microbial species.

Tocopherol esters inhibit human glutathione S-transferase omega.

The molecular mechanism behind the inhibition of hGSTO1-1 by alpha-tocopherol esters (vitamin E) is important for understanding neurodegenerative diseases, which are also influenced by vitamin E.

Progress of studies on glutathione-S-transferase and its correlation with tumor

The over-expression of GST in tumor cells may mediate glutathione to bind on the substrates of anticancer drugs, accordingly leads to drug resistance of tumor.

The functional interactome of GSTP: A regulatory biomolecular network at the interface with the Nrf2 adaption response to oxidative stress.

  • D. BartoliniF. Galli
  • Biology
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2016

Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia

PurposeTo evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL).MethodsThe polymorphism of GSTO1 and

The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study

The findings suggest that the studied polymorphisms might play a significant role in the susceptibility to de novo childhood ALL in Egypt; however, GSTO1*A140D and/or GSTO2*N142D polymorphisms have no impact on ALL prognosis.

Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma

The study indicated that the loss of GSTO2 via DNA hypermethylation contributes to the growth and progression of LSCC, probably by modulating cancer metabolism via the p38/β‐catenin signaling pathway.

Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women

The study suggests that postmenopausal carriers of the GSTO1 *B/*B genotype may be at increased risk of especially estrogen receptor positive breast cancer, in accordance with the only previous study.

No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk

It is unlikely that glutathione S-transferases GSTA2, GSTM2, VATO1, GSTO2, and GSTZ1 participate in breast cancer susceptibility, and no breast cancer risk associations are observed.