Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

@article{Mitchell1996CloningEA,
  title={Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.},
  author={Pratima Mitchell and H A Magna and Lisa Malaine Reeves and Lori L. Lopresti-Morrow and Sue A. Yocum and Philip J Rosner and Kieran F. Geoghegan and John E. Hambor},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 3},
  pages={
          761-8
        }
}
Proteolysis of triple-helical collagen is an important step in the progression toward irreversible tissue damage in osteoarthritis. Earlier work on the expression of enzymes in cartilage suggested that collagenase-1 (MMP-1) contributes to the process. Degenerate reverse transcription polymerase chain reaction experiments, Northern blot analysis, and direct immunodetection have now provided evidence that collagenase-3 (MMP-13), an enzyme recently cloned from human breast carcinoma, is expressed… CONTINUE READING

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