Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel.

@article{McDonald1994CloningEA,
  title={Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel.},
  author={Fiona J. McDonald and Peter M. Snyder and Paul B. McCray and Michael J. Welsh},
  journal={The American journal of physiology},
  year={1994},
  volume={266 6 Pt 1},
  pages={L728-34}
}
Amiloride-sensitive Na+ channels control, in part, fluid and electrolyte transport across epithelia in many organs. In the lung, they control the quantity and composition of the respiratory tract fluid and play a key role in the transition from a fluid-filled lung at the time of birth. Their function may also be altered in a number of diseases. The recent identification of an epithelial Na+ channel from rat colon allowed us to use a probe from that sequence to clone an amiloride-sensitive Na… CONTINUE READING