Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1.

@article{Dong1997CloningEA,
  title={Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1.},
  author={Wei F Dong and Henry H Heng and Robert Lowsky and Yinyan Xu and John F Decoteau and Xiao Mei Shi and Lap Chee Tsui and Mark D Minden},
  journal={DNA and cell biology},
  year={1997},
  volume={16 6},
  pages={671-8}
}
We have identified a putative transcription factor, designated hLim-1, from human fetal brain using degenerate polymerase chain reaction (PCR) and cDNA library screening. The deduced open reading frame, derived from sequencing a 3.0-kb hLim-1 cDNA, encodes a protein of 384 amino acids with two cysteine-rich LIM domains and one homeobox (HOX) DNA-binding domain. The nucleotide sequence of hLim-1 cDNA is 87% identical to mouse Lim-1 and the predicted amino acid sequence is greater than 97… CONTINUE READING