Cloning, expression, and characterization of the trout cardiac Na(+)/Ca(2+) exchanger.

@article{Xue1999CloningEA,
  title={Cloning, expression, and characterization of the trout cardiac Na(+)/Ca(2+) exchanger.},
  author={X. Xue and L. Hryshko and D. Nicoll and K. Philipson and G. Tibbits},
  journal={The American journal of physiology},
  year={1999},
  volume={277 4},
  pages={
          C693-700
        }
}
  • X. Xue, L. Hryshko, +2 authors G. Tibbits
  • Published 1999
  • Chemistry, Medicine
  • The American journal of physiology
  • Isoform 1 of the cardiac Na(+)/Ca(2+) exchanger (NCX1) is an important regulator of cytosolic Ca(2+) concentration in contraction and relaxation. Studies with trout heart sarcolemmal vesicles have shown NCX to have a high level of activity at 7 degrees C, and this unique property is likely due to differences in protein structure. In this study, we describe the cloning of an NCX (NCX-TR1) from a Lambda ZAP II cDNA library constructed from rainbow trout (Oncorhynchus mykiss) heart RNA. The NCX… CONTINUE READING
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