Cloning, expression, and characterization of the trout cardiac Na(+)/Ca(2+) exchanger.

  title={Cloning, expression, and characterization of the trout cardiac Na(+)/Ca(2+) exchanger.},
  author={X. Xue and L. Hryshko and D. Nicoll and K. Philipson and G. Tibbits},
  journal={The American journal of physiology},
  volume={277 4},
  • X. Xue, L. Hryshko, +2 authors G. Tibbits
  • Published 1999
  • Chemistry, Medicine
  • The American journal of physiology
  • Isoform 1 of the cardiac Na(+)/Ca(2+) exchanger (NCX1) is an important regulator of cytosolic Ca(2+) concentration in contraction and relaxation. Studies with trout heart sarcolemmal vesicles have shown NCX to have a high level of activity at 7 degrees C, and this unique property is likely due to differences in protein structure. In this study, we describe the cloning of an NCX (NCX-TR1) from a Lambda ZAP II cDNA library constructed from rainbow trout (Oncorhynchus mykiss) heart RNA. The NCX… CONTINUE READING
    13 Citations
    Teleost fish models in membrane transport research: the PEPT1(SLC15A1) H+–oligopeptide transporter as a case study
    • 28
    Protein cold adaptation strategy via a unique seven-amino acid domain in the icefish (Chionodraco hamatus) PEPT1 transporter
    • 18
    • PDF
    Molecular biology of ion motive proteins in comparative models
    • 13
    • PDF
    Characterisation of intestinal peptide transporter of the Antarctic haemoglobinless teleost Chionodraco hamatus
    • 21
    • PDF
    Triggering of sarcoplasmic reticulum Ca2+ release and contraction by reverse mode Na+/Ca2+ exchange in trout atrial myocytes.
    • 33
    • PDF