Cloning, expression, and characterization of the trout cardiac Na+/Ca2+exchanger.

  title={Cloning, expression, and characterization of the trout cardiac Na+/Ca2+exchanger.},
  author={Xiao-Hua Xue and L. Hryshko and D. Nicoll and K. Philipson and G. Tibbits},
  journal={American journal of physiology. Cell physiology},
  volume={277 4},
  • Xiao-Hua Xue, L. Hryshko, +2 authors G. Tibbits
  • Published 1999
  • Chemistry, Medicine
  • American journal of physiology. Cell physiology
  • Isoform 1 of the cardiac Na+/Ca2+exchanger (NCX1) is an important regulator of cytosolic Ca2+ concentration in contraction and relaxation. Studies with trout heart sarcolemmal vesicles have shown NCX to have a high level of activity at 7°C, and this unique property is likely due to differences in protein structure. In this study, we describe the cloning of an NCX (NCX-TR1) from a Lambda ZAP II cDNA library constructed from rainbow trout ( Oncorhynchus mykiss) heart RNA. The NCX-TR1 cDNA has an… CONTINUE READING
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