Cloning, expression, and characterization of the trout cardiac Na+/Ca2+exchanger.

@article{Xue1999CloningEA,
  title={Cloning, expression, and characterization of the trout cardiac Na+/Ca2+exchanger.},
  author={Xiao-Hua Xue and L. Hryshko and D. Nicoll and K. Philipson and G. Tibbits},
  journal={American journal of physiology. Cell physiology},
  year={1999},
  volume={277 4},
  pages={C693-C700}
}
  • Xiao-Hua Xue, L. Hryshko, +2 authors G. Tibbits
  • Published 1999
  • Chemistry, Medicine
  • American journal of physiology. Cell physiology
    • Isoform 1 of the cardiac Na+/Ca2+exchanger (NCX1) is an important regulator of cytosolic Ca2+ concentration in contraction and relaxation. Studies with trout heart sarcolemmal vesicles have shown NCX to have a high level of activity at 7°C, and this unique property is likely due to differences in protein structure. In this study, we describe the cloning of an NCX (NCX-TR1) from a Lambda ZAP II cDNA library constructed from rainbow trout ( Oncorhynchus mykiss) heart RNA. The NCX-TR1 cDNA has an… CONTINUE READING
    View on PubMed
    doi.org
    43 Citations
    Background Citations
    14
    Methods Citations
    2
    Results Citations
    1
    43 Citations
    Citation Type

    Citation Type

    Temperature dependence of cloned mammalian and salmonid cardiac Na(+)/Ca(2+) exchanger isoforms.
    • 40
    cDNA Cloning and Expression of the Cardiac Na+/Ca2+ Exchanger from Mozambique Tilapia (Oreochromis mossambicus) Reveal a Teleost Membrane Transporter with Mammalian Temperature Dependence*
    • 13
    • PDF
    Determinants of cardiac Na(+)/Ca(2+) exchanger temperature dependence: NH(2)-terminal transmembrane segments.
    • 8
    • PDF
    Temperature dependence of the cardiac sodium calcium exchanger
    • PDF
    Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
    • 2
    • PDF
    Gene Structure Evolution of the Na+-Ca2+ Exchanger (NCX) Family
    • 38
    • PDF
    Molecular determinants of cAMP‐mediated regulation of the Na+–Ca2+ exchanger expressed in human cell lines
    • 26
    Phylogeny of Na+/Ca2+ exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species.
    • 31
    • PDF
    The function of the sarcoplasmic reticulum is not inhibited by low temperatures in trout atrial myocytes.
    • 18
    • PDF
    Characterization of the relationship between Na+–Ca2+ exchange rate and cytosolic calcium in trout cardiac myocytes
    • 30

    References

    SHOWING 1-10 OF 39 REFERENCES
    Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger
    • 740
    Initial localization of regulatory regions of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
    • 264
    • PDF
    A Novel Molecular Determinant for cAMP-dependent Regulation of the Frog Heart Na+-Ca2+Exchanger*
    • 29
    • PDF
    Structure-function analysis of CALX1.1, a Na+-Ca2+ exchanger from Drosophila. Mutagenesis of ionic regulatory sites.
    • 41
    Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
    • 259
    Biosynthesis and initial processing of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
    • 81
    Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms.
    • 233
    Anomalous regulation of the Drosophila Na(+)-Ca2+ exchanger by Ca2+
    • 83
    • PDF
    Regulation of the Cardiac Na+-Ca2+ Exchanger by the Endogenous XIP Region
    • 172
    • PDF
    Mutagenesis Studies of the Cardiac Na+‐Ca2+ Exchanger
    • 10