Cloning, characterization, and comparative activity of turbot IGF-I and IGF-II.

  title={Cloning, characterization, and comparative activity of turbot IGF-I and IGF-II.},
  author={He le Ne Duval and Karine Rousseau and G Eli{\`e}s and Pierre-Yves Le Bail and Sylvie Dufour and Gilles Boeuf and Daniel Boujard},
  journal={General and comparative endocrinology},
  volume={126 3},
IGF peptides belong to a complex system that is known to play a major role in the control of growth and development in mammals. Even if studies performed in nonmammalian species tend to demonstrate an important function of these molecules, use of heterologous ligands, especially in fish, partly limit our knowledge of the physiological role(s) of IGFs. We report in this study the cloning, production, and characterization in an evolved fish, the turbot Psetta maxima, of mature IGF-I and IGF-II… CONTINUE READING

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