Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.

@article{Sheares1989CloningAA,
  title={Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.},
  author={B T Sheares and Sylvia S White and D T Molowa and Kee Chan and Victor D-H. Ding and Paul Anthony Kroon and R G Bostedor and J. D. Karkas},
  journal={Biochemistry},
  year={1989},
  volume={28 20},
  pages={8129-35}
}
A partial length cDNA encoding farnesyl pyrophosphate synthetase (hpt807) has been isolated from a human fetal liver cDNA library in lambda gt11. DNA sequence analysis reveals hpt807 is 1115 bp in length and contains an open reading frame coding for 346 amino acids before reaching a stop codon, a polyadenylation addition sequence, and the first 14 residues of a poly(A+) tail. Considerable nucleotide and deduced amino acid sequence homology is observed between hpt807 and previously isolated rat… CONTINUE READING