Clonidine reverses spatial learning deficits and reinstates θ frequencies in rats with partial fornix section

@article{AmmassariTeule1991ClonidineRS,
  title={Clonidine reverses spatial learning deficits and reinstates θ frequencies in rats with partial fornix section},
  author={Martine Ammassari-Teule and Catherine Maho and Susan Sara},
  journal={Behavioural Brain Research},
  year={1991},
  volume={45},
  pages={1-8}
}
Rats received knife-cuts to the dorsal fornix or sham-operations. Half of the animals from each group were injected with clonidine (0.01 mg/kg) and the others with saline before each daily trail of a 10-trial radial 8-arm maze task. The number of choices before the first repetition and the run time were used as performance indices. Lesioned rats were significantly impaired in the acquisition of this task. Clonidine-treated rats, lesioned or not, had an acquisition profile indistinguishable from… CONTINUE READING

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