Clonidine potentiates drug induced self-injurious behavior in rats

@article{Mueller1983ClonidinePD,
  title={Clonidine potentiates drug induced self-injurious behavior in rats},
  author={Kathyrne Jean Mueller and William L. Nyhan},
  journal={Pharmacology Biochemistry and Behavior},
  year={1983},
  volume={18},
  pages={891-894}
}
  • K. Mueller, W. Nyhan
  • Published 31 December 1983
  • Medicine
  • Pharmacology Biochemistry and Behavior
Caffeine and amphetamine have been regarded as dramatically dissimilar drugs, both structurally and behaviorally. However, both are stimulants and (under certain conditions) both produce self-injurious behavior in rats which is potentiated by clonidine. Rats were pretreated with various doses of clonidine prior to daily administration of caffeine. In another experiment, rats which had been implanted with continuous release amphetamine pellets were injected twice daily with various doses of… 
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Functional analysis by analog methodology indicated different functions for two forms of SIB shown by the subject: automatic reinforcement by sensory stimulation and escape from social interactions, and it was suggested that features of Rett syndrome established conditions under which operant conditioning of self-injurious responding was maximized.
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