Clonidine potentiates drug induced self-injurious behavior in rats

@article{Mueller1983ClonidinePD,
  title={Clonidine potentiates drug induced self-injurious behavior in rats},
  author={K. Mueller and W. Nyhan},
  journal={Pharmacology Biochemistry and Behavior},
  year={1983},
  volume={18},
  pages={891-894}
}
  • K. Mueller, W. Nyhan
  • Published 1983
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • Caffeine and amphetamine have been regarded as dramatically dissimilar drugs, both structurally and behaviorally. However, both are stimulants and (under certain conditions) both produce self-injurious behavior in rats which is potentiated by clonidine. Rats were pretreated with various doses of clonidine prior to daily administration of caffeine. In another experiment, rats which had been implanted with continuous release amphetamine pellets were injected twice daily with various doses of… CONTINUE READING
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