Clonidine-induced sedation in rats: Evidence for mediation by postsynapticα 2-adrenoreceptors

@article{Spyraki2005ClonidineinducedSI,
  title={Clonidine-induced sedation in rats: Evidence for mediation by postsynapticα 2-adrenoreceptors},
  author={Christina Spyraki and H. Christian Fibiger},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={54},
  pages={153-163}
}
The effect of low doses of clonidine on exploration and motility was investigated in rats after destruction of central noradrenergic systems by 6-hydroxydopamine (6-OHDA) or DSP-4. In accordance with previous results, clonidine decreased exploration and motility in control animals. This sedative effect of clonidine was potentiated in animals that suffered… CONTINUE READING