Clonidine in paediatric anaesthesia: review of the literature and comparison with benzodiazepines for premedication

@article{Bergendahl2006ClonidineIP,
  title={Clonidine in paediatric anaesthesia: review of the literature and comparison with benzodiazepines for premedication},
  author={H. T. G. Bergendahl and Per‐Arne L{\"o}nnqvist and Staffan Eksborg},
  journal={Acta Anaesthesiologica Scandinavica},
  year={2006},
  volume={50}
}
Background:  Children undergoing anaesthesia and surgery can experience significant anxiety and distress during the peri‐operative period, but whether routine premedication is necessary is currently debated. 
Adjuncts should always be used in pediatric regional anesthesia
A number of different adjuncts to local anesthetics can be used to prolong and optimize postoperative pain relief following regional anesthesia in children. The present text provides a slightly
Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies
TLDR
A meta‐analysis of studies comparing premedication with clonidine to Benzodiazepines found thatClonidine, an α2 adrenoceptor agonist, is gaining popularity among anesthesiologists.
Intravenous clonidine infusion in infants after cardiovascular surgery
TLDR
Investigation of the hemodynamic profile and heart rhythm in infants who were given intravenous clonidine infusion after prolonged analgesia/sedation following cardiac surgery found no change in heart rhythm or hemodynamic profiles.
Does clonidine premedication decrease postoperative pain in children?
Overall, clonidine premedication at high doses (4–5 μg/kg) may reduce the use of postoperative analgesia in children. Additionally, it may reduce nausea and vomiting and the time in the recovery or
An Evidence-Based Guideline for the Pre-Operative Sedation of Children
TLDR
For the anxious but cooperative child, oral midazolam is often adequate; however with more anxious younger and uncooperative children, combined oral midAZolam and ketamine is more effective.
Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children
TLDR
The aim of this study was to evaluate the influence of three different premedication regimens on postoperative pain and anxiety in children.
Onset time for pharmacologic premedication with clonidine as a nasal aerosol: a double‐blind, placebo‐controlled, randomized trial
TLDR
It is proposed that nasal aerosol clonidine can reduce the onset time of preoperative sedation and this research could help to reduce the need for repeat operations.
Paediatric day-case anaesthesia and pain control
TLDR
Children benefit particularly from day care and recent advances in anaesthesia and pain management have allowed a huge expansion of this modality of care with a consequent reduction in the need for children to be in hospital.
Incidence of bradycardia at arrival to the operating room after oral or intravenous premedication with clonidine in children
TLDR
The aim of this study was to investigate the incidence of bradycardia in children premedicated with oral or intravenous clonidine as compared to children not receiving pharmacologic premedication.
Preoperative anxiety in preschool children: A randomized clinical trial comparing midazolam, clonidine, and dexmedetomidine
TLDR
Compared the effect of three different premedications on anxiety before anesthesia induction in preschool children aged 2−6 years scheduled for elective surgery, secondary outcomes comprised distress during peripheral catheter (PVC) insertion, compliance at anesthesia induction, and level of sedation.
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The aim of the study was to determine whether caudal S‐ketamine or clonidine prolonged analgesia together with ropivacaine contributed to pain relief in patients with chronic pain.
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