Clonidine in mania

@article{Giannini1983ClonidineIM,
  title={Clonidine in mania},
  author={A. Giannini and I. Extein and M. Gold and A. Pottash and S. Castellani},
  journal={Drug Development Research},
  year={1983},
  volume={3}
}
Hyperactivity of central noradrenergic neurotransmission has been implicated in the pathophysiology of mania. This theory suggests that clonidine, an antihypertensive medication that decreases the activity of central noradrenergic neurons by presynaptic inhibitory effect, has antimanic properties. We administered clonidine orally in a dosage of 17 μg/kg/day to 11 hypomanic or manic patients. Biegel‐Murphy Manic‐State Rating Scale scores were significantly decreased compared to pretreatment… Expand
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