Clonidine decreases stress response in patients undergoing carotid endarterectomy under regional anesthesia: a prospective, randomized, double-blinded, placebo-controlled study.

@article{Schneemilch2006ClonidineDS,
  title={Clonidine decreases stress response in patients undergoing carotid endarterectomy under regional anesthesia: a prospective, randomized, double-blinded, placebo-controlled study.},
  author={Christine E Schneemilch and Holger Bachmann and Anke Ulrich and Regine Elwert and Zuhir Halloul and Thomas Hachenberg},
  journal={Anesthesia and analgesia},
  year={2006},
  volume={103 2},
  pages={297-302, table of contents}
}
Inadequate analgesia or anxiety may induce an increased stress response in patients undergoing carotid endarterectomy (CEA) under regional anesthesia (RA). Central alpha2 adrenoceptor agonists have significant sedative and analgesic properties, which may attenuate sympathoadrenal activation during CEA and improve the quality of RA. We randomly assigned 80 patients to 2 groups receiving either RA plus placebo (n = 40) or RA plus clonidine 1 microg/kg as the initial loading dose followed by 1… CONTINUE READING
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