Clonidine complexation with hydroxypropyl-beta-cyclodextrin: From physico-chemical characterization to in vivo adjuvant effect in local anesthesia.

Abstract

Clonidine (CND), an alpha-2-adrenergic agonist, is used as an adjuvant with local anesthetics. In this work, we describe the preparation and characterization of an inclusion complex of clonidine in hydroxypropyl-beta-cyclodextrin (HP-β-CD), as revealed by experimental (UV-vis absorption, SEM, X-ray diffraction, DOSY- and ROESY-NMR) and theoretical… (More)
DOI: 10.1016/j.jpba.2015.11.015

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Cite this paper

@article{Braga2016ClonidineCW, title={Clonidine complexation with hydroxypropyl-beta-cyclodextrin: From physico-chemical characterization to in vivo adjuvant effect in local anesthesia.}, author={Marta Braga and M Florencia Martini and M{\'o}nica Pickholz and Fabiano Yokaichiya and Mosca Franco and Lu{\'i}s Fernando Cabeça and Vladimir Guilherme and C. M. G. Silva and Cintia Elizabeth Gomez Limia and Eneida de Paula}, journal={Journal of pharmaceutical and biomedical analysis}, year={2016}, volume={119}, pages={27-36} }