Clonidine antagonism of angiotensin-related drinking: a central site of action.

Abstract

Administration of either isoproterenol (25 micrograms/kg, s.c.) or angiotensin II (200 micrograms/kg, s.c.) induces drinking in rats within 0.5-1 h. This drinking was inhibited by prior administration of the presynaptic alpha-adrenergic agonist clonidine (12 micrograms/kg, i.p.). Urine output was enhanced by clonidine in the angiotensin II-, but not the… (More)

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@article{Fregly1984ClonidineAO, title={Clonidine antagonism of angiotensin-related drinking: a central site of action.}, author={Melvin J. Fregly and Nathan Rowland and Joyce Greenleaf}, journal={Brain research}, year={1984}, volume={298 2}, pages={321-7} }