Clonidine and guanfacine-induced antinociception in visceral pain: possible role of alpha 2/I2 binding sites.

@article{Sabetkasaie2004ClonidineAG,
  title={Clonidine and guanfacine-induced antinociception in visceral pain: possible role of alpha 2/I2 binding sites.},
  author={Masoumeh Sabetkasaie and Setareh Vala and Niaz Khansefid and Ali-Reza Hosseini and Mohammad-Ali Raies Sadat Ladgevardi},
  journal={European journal of pharmacology},
  year={2004},
  volume={501 1-3},
  pages={95-101}
}
Visceral pain is one of the most common forms of pain which is poorly understood. We now studied the influence of imidazoline/guanidinium compounds such as clonidine and guanfacine on visceral pain in the presence or absence of yohimbine and benazoline. To produce visceral pain-related behaviours, formalin (10%) was administered by inserting a fine cannula into the colon via the anus. Each experiment took 1 h. Clonidine (0.001, 0.01 and 0.1 mg/kg, i.p.) and guanfacine (2.5, 5 and 10 mg/kg, i.p… CONTINUE READING

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