Clonidine and guanfacine in hypertension.

  title={Clonidine and guanfacine in hypertension.},
  author={Adesh K. Jain and Anand N. Hiremath and Roggendorf Michael and Jerome R. Ryan and F. Gilbert Mcmahon},
  journal={Clinical pharmacology and therapeutics},
  volume={37 3},
  • Adesh K. Jain, Anand N. Hiremath, +2 authors F. Gilbert Mcmahon
  • Published in
    Clinical pharmacology and…
  • Medicine
  • Guanfacine, 1 to 3 mg/day, and clonidine, 0.1 to 0.3 mg twice a day, were compared in a 24-week double-blind, randomized, parallel study of 42 patients with hypertension that was inadequately treated by chlorthalidone, 25 mg/day. Mean reduction of blood pressure was 18/9 mm Hg after guanfacine and 14/8 mm Hg after clonidine. To determine the incidence of rebound hypertension, subjects were hospitalized for 7 days during chlorthalidone therapy for collection of baseline data and once again… CONTINUE READING

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