Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine.

@article{Kleid1981ClonedVP,
  title={Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine.},
  author={Dennis G. Kleid and Daniel G. Yansura and Barbara J. Small and Donald Dowbenko and Dawn M. Moore and Marvin J. Grubman and P. Mckercher and Dr Trefor O. Morgan and Betty H. Robertson and Howard L. Bachrach},
  journal={Science},
  year={1981},
  volume={214 4525},
  pages={
          1125-9
        }
}
A DNA sequence coding for the immunogenic capsid protein VP3 of foot-and-mouth disease virus A12, prepared from the virion RNA, was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system. When Escherichia coli transformed with this plasmid was grown in tryptophan-depleted media, approximately 17 percent of the total cellular protein was found to be an insoluble and stable chimeric protein. The purified chimeric protein competed… CONTINUE READING
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