Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro.

@article{Haruki2005ClonedFP,
  title={Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro.},
  author={Nobuhiro Haruki and Keiko S Kawaguchi and Shannon Eichenberger and Pierre P. Massion and Agust{\'i} Gonz{\'a}lez and Adi F. Gazdar and John D. Minna and David P Carbone and Thao Thi Phuong Dang},
  journal={Journal of medical genetics},
  year={2005},
  volume={42 7},
  pages={
          558-64
        }
}
BACKGROUND Somatically acquired chromosomal translocation is a common mechanism of oncogene activation in many haematopoietic tumours and sarcomas. However, very few recurrent chromosomal translocations have been reported in more common epithelial tumours such as lung carcinomas. METHODS We established a cell line HCC2429 from an aggressive, metastatic lung cancer arising in a young, non-smoking woman, demonstrating a t(15;19)(q13.2;p13.1). The breakpoints on chromosomes 15 and 19 were cloned… CONTINUE READING

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