Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

@article{Romero1989ClonedCT,
  title={Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria},
  author={Pedro Romero and Janet L. Maryanski and Giampietro Corradin and Ruth Sonntag Nussenzweig and Victor Nussenzweig and Fidel P. Zavala},
  journal={Nature},
  year={1989},
  volume={341},
  pages={323-326}
}
PROTECTIVE immunity against malaria is induced by vaccination of hosts with irradiation-attenuated sporozoites. This immunity is mediated in part by neutralizing antibodies that are directed mainly against the repeat domain of the circumsporozoite protein1–4. Early experiments showed, however, that B-cell-depleted mice that are immunized with sporozoites… CONTINUE READING