Cloned cattle fetuses with the same nuclear genetics are more variable than contemporary half-siblings resulting from artificial insemination and exhibit fetal and placental growth deregulation even in the first trimester.

@article{Lee2004ClonedCF,
  title={Cloned cattle fetuses with the same nuclear genetics are more variable than contemporary half-siblings resulting from artificial insemination and exhibit fetal and placental growth deregulation even in the first trimester.},
  author={Rita S F Lee and Amanda J. Peterson and Martyn J Donnison and Susan R Ravelich and Anita M Ledgard and Ning Li and Jan E Oliver and Andria L Miller and Fleur C Tucker and Bernhard Breier and D. N. Wells},
  journal={Biology of reproduction},
  year={2004},
  volume={70 1},
  pages={1-11}
}
The cloning of cattle by somatic cell nuclear transfer (NT) is associated with a high incidence of abnormal placentation, excessive fluid accumulation in the fetal sacs (hydrops syndrome), and fetal overgrowth. Fetal and placental development was investigated at Day 50, during placentome formation; at Day 100, when placentation was completed; and at Day 150, when the hydrops syndrome frequently develops. The NT fetuses were compared with contemporary half-siblings generated from in vitro… CONTINUE READING

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