Cloned Cattle Can Be Healthy and Normal

@article{Lanza2001ClonedCC,
  title={Cloned Cattle Can Be Healthy and Normal},
  author={Robert Lanza and Jose Bernardo Cibelli and D Faber and Raymond W. Sweeney and B Henderson and Wendy K. Nevala and Michael D West and Peter J. Wettstein},
  journal={Science},
  year={2001},
  volume={294},
  pages={1893 - 1894}
}
The possibility of cloning humans has raised questions as to whether nuclear transfer can be used to reproducibly generate healthy adult animals. Reports in the popular and scientific press on genetic, immunological, and other developmental problems raise the question of whether there are “any 
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Somatic cell nuclear transfer.
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This work has shown that when a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
Cloning cattle: the methods in the madness.
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  • Biology, Medicine
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  • 2007
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The phenotypic abnormality of the G1 clone is likely to be due to epigenetic dysregulation, and global methylation changes during development of the preimplantation embryos reconstructed by donor cells used for the production of G1 and G2 clones were analyzed.
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References

SHOWING 1-7 OF 7 REFERENCES
Don't Clone Humans!
TLDR
Research into cloning specific cells for repair and regeneration of tissues would likely suffer from public reaction to human cloning failures, because the technology for detecting genetic abnormalities used in routine prenatal diagnosis cannot detect problems in epigenetic programming.
Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.
TLDR
Six healthy cloned calves derived from populations of senescent donor somatic cells are reported on, showing the ability to regenerate animals and cells and the telomeres were extended beyond those of newborn (<2 weeks old) and age-matched control animals.
A novel cell surface proliferation‐associated marker expressed on T cells and up‐regulated on germinal center B cells
TLDR
A novel cell surface antigen recognized by monoclonal antibody VPM30, originally thought to recognize only bovine and ovine sIg+ B cells from peripheral blood, is shown to be novel, corresponding to no known cluster of differentiation, and will be of great use in the study of ruminant cellular immune responses.
Cloned transgenic calves produced from nonquiescent fetal fibroblasts.
TLDR
The life-span of near senescent fibroblasts could be extended by nuclear transfer, as indicated by population doublings in fibroblast lines derived from a 40-day-old fetal clone.