Cloned Cattle Can Be Healthy and Normal

  title={Cloned Cattle Can Be Healthy and Normal},
  author={Robert Lanza and Jose Bernardo Cibelli and D Faber and Raymond W. Sweeney and B Henderson and Wendy K. Nevala and Michael D West and Peter J. Wettstein},
  pages={1893 - 1894}
The possibility of cloning humans has raised questions as to whether nuclear transfer can be used to reproducibly generate healthy adult animals. Reports in the popular and scientific press on genetic, immunological, and other developmental problems raise the question of whether there are “any 
Are there any normal cloned mammals?
The finding that cloned mice, produced by transfer of nuclei from cumulus cells, develop obesity but do not transmit the phenotype to their offspring provides further evidence that cloned embryos are
Human cloning: can it be made safe?
There are continued claims of attempts to clone humans using nuclear transfer, despite the serious problems that have been encountered in cloning other mammals. It is known that epigenetic and
Health and neonatal care of bovine clones.
The methodology discussed in this chapter is based largely on a double corticosteroid regime to induce parturition and fetal organ maturation in bovine clones.
The immune status of bovine somatic clones.
Previous data suggesting that cloned cattle have a normal immunity are supported, as they were able to raise an antibody response and to develop B and T cell-specific responses against the model antigen OVA (ovalbumin) and against a rotavirus vaccine as in controls.
Animal cloning: problems and prospects.
  • D. Wells
  • Biology
    Revue scientifique et technique
  • 2005
Initial confidence is provided in the first application of NT in agriculture, namely, the production of small numbers of cloned sires from genetically elite bulls, for natural mating, to effectively disseminate genetic gain.
Somatic cell nuclear transfer
This work has shown that when a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
Somatic cell nuclear transfer.
This work has shown that when a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
Cloning cattle: the methods in the madness.
  • B. Oback, D. Wells
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 2007
This paper reviews current cattle cloning methodologies and their potential technical or biological pitfalls at any step of the procedure, and focuses on one methodological parameter, namely donor cell selection.
Serial cloning of pigs by somatic cell nuclear transfer: Restoration of phenotypic normality during serial cloning
The phenotypic abnormality of the G1 clone is likely to be due to epigenetic dysregulation, and global methylation changes during development of the preimplantation embryos reconstructed by donor cells used for the production of G1 and G2 clones were analyzed.


Don't Clone Humans!
Research into cloning specific cells for repair and regeneration of tissues would likely suffer from public reaction to human cloning failures, because the technology for detecting genetic abnormalities used in routine prenatal diagnosis cannot detect problems in epigenetic programming.
Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.
Six healthy cloned calves derived from populations of senescent donor somatic cells are reported on, showing the ability to regenerate animals and cells and the telomeres were extended beyond those of newborn (<2 weeks old) and age-matched control animals.
A novel cell surface proliferation‐associated marker expressed on T cells and up‐regulated on germinal center B cells
A novel cell surface antigen recognized by monoclonal antibody VPM30, originally thought to recognize only bovine and ovine sIg+ B cells from peripheral blood, is shown to be novel, corresponding to no known cluster of differentiation, and will be of great use in the study of ruminant cellular immune responses.
Cloned transgenic calves produced from nonquiescent fetal fibroblasts.
The life-span of near senescent fibroblasts could be extended by nuclear transfer, as indicated by population doublings in fibroblast lines derived from a 40-day-old fetal clone.