Clone-based systematic haplotyping (CSH): a procedure for physical haplotyping of whole genomes.

Abstract

We present a novel methodology to determine the phase of single-nucleotide polymorphisms (SNPs) on a chromosome, which we term clone-based systematic haplotyping (CSH). The CSH procedure is based on separating the allelic chromosomes of a diploid genome by fosmid/cosmid cloning, and subsequent SNP typing of 96 clone pools, each representing approximately 10… (More)

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@article{Burgtorf2003ClonebasedSH, title={Clone-based systematic haplotyping (CSH): a procedure for physical haplotyping of whole genomes.}, author={Carola Burgtorf and Pamela Kepper and Margret R. Hoehe and Carsten Schmitt and Richard Reinhardt and Hans Lehrach and Sascha Sauer}, journal={Genome research}, year={2003}, volume={13 12}, pages={2717-24} }