Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features

@article{Lerner2003ClonazepamTO,
  title={Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features},
  author={Arturo G. Lerner and Marc Gelkopf and Irena Skladman and Dmitri Rudinski and Hanna Nachshon and Avi Bleich},
  journal={International Clinical Psychopharmacology},
  year={2003},
  volume={18},
  pages={101-105}
}
An unique and intriguing characteristic of lysergic acid diethylamide (LSD) and LSD-like substances is the recurrence of some of the symptoms which appear during the intoxication, in the absence of recent intake of hallucinogens. Hallucinogen persisting perception disorder (HPPD) is a condition in which the re-experiencing of one or more perceptual symptoms causes significant distress or impairment in social, occupational or other important areas of functioning and may be extremely debilitating… 
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Ropinirole may offer a novel treatment for patients with Hallucinogen persisting perception disorder, and more research is needed to determine the suitability of dopamine agonists in the treatment for HPPD.
Hallucinogen-persisting perception disorder
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Based on its hypothesized neuroprotective and mood-stabilizing effects, the antiepileptic lamotrigine may offer a promising new approach in the treatment of HPPD.
Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives
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The aims of the present study are to review all the original studies about HPPD in order to provide readers with the most updated and comprehensive literature review about the clinical features and treatment options for HPPD.
Hallucinogen Persisting Perception Disorder (HPPD) and Flashback-are they Identical?
TLDR
With its potentially neuroprotective and mood-stabilising properties, lamotrigine may offer a promising new therapeutic approach for the treatment of Hallucinogen persisting perception disorder.
Clonazepam in the treatment of psychiatric disorders: an update
  • A. Nardi, G. Perna
  • Psychology, Medicine
    International clinical psychopharmacology
  • 2006
TLDR
Evidence for the use of clonazepam in acute mania and as augmentation therapy with SSRIs to accelerate response in depression is examined and the long half-life and higher potency of clonsodiazepine may allow easier discontinuation with fewer withdrawal symptoms compared to other benzodiazepines.
Hallucinogen Persisting Perception Disorder and Risk of Suicide
TLDR
Although hallucinogen abuse is common in the United States, this case suggests that HPPD maybe significantly underdiagnosed and undertreated and in some cases, this oversight may perpetuate years of unnecessary patient suffering and can ultimately lead to severe depression and suicide.
Hallucinogen persisting perceptual disorder: a scoping review covering frequency, risk factors, prevention and treatment.
TLDR
The renewed interest in psychedelics for select mental disorders, especially agents with hallucinogenic potential provides the impetus to characterize Hallucinogen persisting perception disorder in its frequency, risk and protective factors, key characteristics, as well as other clinical and treatment related factors.
[Hallucinogen Persisting Perception Disorder (HPPD) and Flashback Phenomena – Differential Diagnosis and Explanation Models].
TLDR
Hallucinogen Persisting Perception Disorder appears to be further a DSM-5-genuine but still puzzling disorder, and the different consequences including new therapeutic approaches are discussed in clinical context.
The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review
TLDR
A critical mini review on psychopathological bases, etiological hypothesis, and psychopharmacological approaches toward HPPD, including the association with some novel substances, are provided here, by means of a literature search on PubMed/Medline, Google Scholar, and Scopus databases without time restrictions.
Other Times I Can Barely See: The Effects of Hallucinogens on Vision and Attention
TLDR
Two double-blind placebo-controlled experiments on the effects of the serotonergic drugs 3,4-methylenedioxyamphetamine (MDA) and 3, 4- methylenedioxymethamphetamine (MDMA) on attention to emotional stimuli and preliminary evidence that MDA and MDMA may modify processing of threat-related stimuli is found.
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