Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features

@article{Lerner2003ClonazepamTO,
  title={Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features},
  author={Arturo G. Lerner and Marc Gelkopf and Irena Skladman and Dmitri Rudinski and Hanna Nachshon and Avi Bleich},
  journal={International Clinical Psychopharmacology},
  year={2003},
  volume={18},
  pages={101-105}
}
An unique and intriguing characteristic of lysergic acid diethylamide (LSD) and LSD-like substances is the recurrence of some of the symptoms which appear during the intoxication, in the absence of recent intake of hallucinogens. Hallucinogen persisting perception disorder (HPPD) is a condition in which the re-experiencing of one or more perceptual symptoms causes significant distress or impairment in social, occupational or other important areas of functioning and may be extremely debilitating… 
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References

SHOWING 1-10 OF 46 REFERENCES
Flashback and Hallucinogen Persisting Perception Disorder: clinical aspects and pharmacological treatment approach.
TLDR
Pharmacological agents such as clonidine, perphenazine and clonazepan have been shown to ameliorate this recurring syndrome in some of the individuals seeking treatment.
LSD-induced Hallucinogen Persisting Perception Disorder treated with clonazepam: two case reports.
TLDR
Two out-patients with LSD-induced HPPD were successfully treated with clonazepam, which has serotonergic properties, and reported a marked improvement and only mild symptomatology which persisted during a six month follow-up period.
Adverse consequences of lysergic acid diethylamide.
TLDR
Current data confirm earlier findings of long lasting psychopathology arising in vulnerable individuals from the use of LSD, and a hypothetical long term molecular mechanism of adverse effects is proposed.
Clomipramine, Clonazepam, and Clonidine Treatment of Obsessive‐Compulsive Disorder
TLDR
The results confirm the efficacy of clomipramine in the treatment of OCD and suggest that clonazepam might be a useful alternative treatment for patients with this disorder.
LSD-like panic from risperidone in post-LSD visual disorder.
TLDR
It is concluded that HPPD may be a relative contraindication for the use of risperidone, because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors.
Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults.
The Psychopharmacology of Hallucinogens
Guidelines for the rational use of benzodiazepines. When and what to use.
TLDR
Indications for benzodiazepines include acute stress reactions, episodic anxiety, fluctuations in generalised anxiety, and as initial treatment for severe panic and agoraphobia, and occasionally in acute psychoses.
LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents.
Clonazepam prescribing patterns and abuse by methadone patients in a medical center setting.
  • D. Trudeau
  • Medicine, Psychology
    Journal of addictive diseases
  • 1994
TLDR
Methadone patients who require inhospital detoxification from self-administered clonazepam (CZM) were interviewed and CZM was the most commonly "excessively" prescribed benzodiazepine.
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5
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