Clonazepam in the treatment of psychiatric disorders: an update

  title={Clonazepam in the treatment of psychiatric disorders: an update},
  author={Ant{\^o}nio Eg{\'i}dio Nardi and Giampaolo Perna},
  journal={International Clinical Psychopharmacology},
  • A. Nardi, G. Perna
  • Published 1 May 2006
  • Psychology, Medicine, Biology
  • International Clinical Psychopharmacology
An updated overview over the past decade is provided with respect to the use of clonazepam in a variety of psychiatric disorders. The efficacy of clonazepam monotherapy for the short-term treatment of panic disorder (PD) was fully established in two large pivotal multicentre studies in the late 1990s in a total of >800 patients. Other studies support a role for clonazepam, in association with selective serotonin reuptake inhibitors (SSRIs), to accelerate treatment response in PD. Although some… 

Clonazepam for the treatment of panic disorder.

It has been shown that panic attacks can more readily be induced by CO2 in PD patients with the respiratory subtype than those with the non-respiratory subtype, and clonazepam, alone or combined with selective serotonin reuptake inhibitors and/or behavioral therapy remains an important therapeutic modality for the management of PD.

Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review

  • S. Morishita
  • Psychology, Medicine
    Human psychopharmacology
  • 2009
Low‐dose, long‐term treatment with clonazepam exhibits a prophylactic effect against recurrence of depression, and is significantly more effective for unipolar than for bipolar depression.

Risks and benefits of medications for panic disorder: a comparison of SSRIs and benzodiazepines

Despite strong evidence of the effectiveness of SSRIs and benzodiazepines in the treatment of PD, few trials have performed head-to-head comparisons of these two drug classes, which could help improve the evidence-based pharmacotherapy of PD.

The Efficacy and Safety of Clonazepam in Patients with Anxiety Disorder Taking Newer Antidepressants: A Multicenter Naturalistic Study

  • Sheng-Min WangJung-Bum Kim Kyoung-Uk Lee
  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2016
It is suggested that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders and the safety profile of clonazerepam was superior to the other Benzodiazepine groups in this study.

Emerging drugs for panic disorder

Defining biomarkers and endophenotypes in PD may offer advantages in both understanding the pathophysiology of the disorder and selecting appropriate targets and outcomes for planning future pharmacological research.

Psychopharmacotherapy of panic disorder: 8-week randomized trial with clonazepam and paroxetine.

  • A. NardiA. M. Valença M. Versiani
  • Psychology, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2011
This naturalistic study confirms the efficacy and tolerability of clonazepam and paroxetine in the acute treatment of patients with panic disorder.

Psychopharmacotherapy of panic disorder: 8-week randomized trial with clonazepam and paroxetine

This naturalistic study confirms the efficacy and tolerability of clonazepam and paroxetine in the acute treatment of patients with panic disorder.

Optimization of Clonazepam Therapy Adjusted to Patient’s CYP3A Status and NAT2 Genotype

Prospective assaying of CYP3A4 expression and N-acetyl transferase 2 acetylator phenotype can better identify the patients with higher risk of adverse reactions and can facilitate the improvement of personalized clonazepam therapy and withdrawal regimen.

A Practitioner’s Guide to Prescribing Clonazepam for Adults with Intellectual Disabilities

The procedures contained in this guideline may not fully account for all of the possible risks of treatment in this population because of the limited studies available; thus, there will be a need to periodically update this guideline as new information becomes available.



Long-term experience with clonazepam in patients with a primary diagnosis of panic disorder.

Treatment of panic disorder with the HPB clonazepam achieved and maintained a therapeutic benefit similar to that obtained with alternative pharmacologic treatments, without the development of tolerance as manifested by dose escalation or worsening of clinical status.

The development of clonazepam as a psychotropic: the massachusetts general hospital experience.

  • J. Rosenbaum
  • Medicine, Psychology
    The Journal of clinical psychiatry
  • 2004
In response to the apparent problematic pharmacokinetics of alprazolam, members of the MGH psychiatry department pursued investigation that ultimately established the antipanic efficacy of clonazepam as well as examined its effectiveness in the treatment of other disorders, such as bipolar disorder and social phobia.

Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder

Early coadministration of clonazepam with sertraline for panic disorder.

The data indicate that rapid stabilization of panic symptoms can be safely achieved with a sertraline/clonazepam combination, supporting the clinical utility of this type of regimen for facilitating early improvement ofpanic symptoms relative to sERTraline alone.

[Effectiveness of clonazepam in depressive disorders].

No correlation was found between the effect of clonazepam and sex, the patients' age, duration of the depressive disorder, period of the index episode and severity of depression, and the authors recorded fatigue and sleepiness and hypotension at the onset of treatment and after larger daily doses.

Clonazepam in childhood anxiety disorders.

Clonazepam was believed to have clinical benefit for some children, but this was not confirmed statistically in this small sample, and side effects of drowsiness and disinhibition were common and possibly were due to rapid titration.

Combined Paroxetine and Clonazepam Treatment Strategies Compared to Paroxetine Monotherapy for Panic Disorder

Combined treatment with paroxetine and clonazepam resulted in more rapid response than with the SSRI alone, but there was no differential benefit beyond the initial few weeks of therapy.

A Double-Blind, Placebo-Controlled Trial of Clonazepam in Obsessive-Compulsive Disorder

  • E. HollanderA. KaplanS. Stahl
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2003
It is suggested that clonazepam is not effective as monotherapy in treating OCD, and its effectiveness in specific subgroups of OCD patients with co-morbid anxiety disorders or as an augmentation strategy added to SSRIs remains to be determined.

Clonazepam in the treatment of prolonged depression.

High-potency benzodiazepines: recent clinical results.

  • G. Moroz
  • Medicine, Psychology
    The Journal of clinical psychiatry
  • 2004
A new, extended-release formulation of alprazolam now allows for once-daily rather than t.i.d. or q.i .d.