Clonazepam in the treatment of prolonged depression.

  title={Clonazepam in the treatment of prolonged depression.},
  author={Shigeru Morishita and Shozo Aoki},
  journal={Journal of affective disorders},
  volume={53 3},
BACKGROUND The purpose of this paper was to examine the optimal adjunctive dose of clonazepam for the treatment of prolonged depression. METHODS Sixty nine patients with prolonged depression were enrolled in an open trial over a 4 week period during which clonazepam was added to their medication. RESULTS A daily dose of 3.0 mg clonazepam as augmentation was significantly more effective than doses of 1.5 mg and below. Most of the improved patients showed a rapid onset of action within 2… CONTINUE READING