Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements

@article{Wagner2003ClonallyEC,
  title={Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements},
  author={U. Wagner and M. Pierer and S. Kaltenh{\"a}user and B. Wilke and W. Seidel and S. Arnold and H. H{\"a}ntzschel},
  journal={European Journal of Immunology},
  year={2003},
  volume={33}
}
  • U. Wagner, M. Pierer, +4 authors H. Häntzschel
  • Published 2003
  • Biology, Medicine
  • European Journal of Immunology
    • Clonally expanded, autoreactive CD4+CD28null cells can be found in the peripheral blood of patients with rheumatoid arthritis and have been shown to be associated with severeextra‐articular disease manifestations. We investigated the size of the CD4+CD28null compartment and the TCR β chain repertoire of expanded CD4+ clonotypes in 94 rheumatoid arthritis patients by complementarity‐determining region 3 (CDR3) length analysis (spectratyping) in the BV6 and BV14 TCR families, with primers… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.
    • 484
    The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis
    • 125
    Expansion of unusual CD4+ T cells in severe rheumatoid arthritis.
    • 296
    Perturbation of the T cell repertoire in rheumatoid arthritis.
    • 257
    • PDF
    Functional subsets of CD4 T cells in rheumatoid synovitis.
    • 209
    High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses.
    • 72
    Peripheral Blood and Granuloma CD4+CD28− T Cells Are a Major Source of Interferon-γ and Tumor Necrosis Factor-α in Wegener’s Granulomatosis
    • 182
    Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.
    • 284
    • PDF
    Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis.
    • 66
    Aging-related Deficiency of CD28 Expression in CD4+ T Cells Is Associated with the Loss of Gene-specific Nuclear Factor Binding Activity*
    • 181
    • PDF