Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements

@article{Wagner2003ClonallyEC,
  title={Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements},
  author={U. Wagner and M. Pierer and S. Kaltenh{\"a}user and B. Wilke and W. Seidel and S. Arnold and H. H{\"a}ntzschel},
  journal={European Journal of Immunology},
  year={2003},
  volume={33}
}
  • U. Wagner, M. Pierer, +4 authors H. Häntzschel
  • Published 2003
  • Biology, Medicine
  • European Journal of Immunology
  • Clonally expanded, autoreactive CD4+CD28null cells can be found in the peripheral blood of patients with rheumatoid arthritis and have been shown to be associated with severeextra‐articular disease manifestations. We investigated the size of the CD4+CD28null compartment and the TCR β chain repertoire of expanded CD4+ clonotypes in 94 rheumatoid arthritis patients by complementarity‐determining region 3 (CDR3) length analysis (spectratyping) in the BV6 and BV14 TCR families, with primers… CONTINUE READING
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