Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM.

@article{Lanz2022ClonallyEB,
  title={Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM.},
  author={Tobias V. Lanz and R Camille Brewer and Peggy Pui-Kay Ho and Jae-Seung Moon and Kevin M. Jude and Daniel Fernandez and Ricardo A. Fernandes and Alejandro M Gomez and Gabriel-Stefan Nadj and Christopher M. Bartley and Ryan D. Schubert and Isobel A. Hawes and Sara E. Vazquez and Manasi Iyer and J. Bradley Zuchero and Bianca Teegen and Jeffrey E. Dunn and Christopher B. Lock and Lucas B. Kipp and Victoria C. Cotham and Beatrix Ueberheide and Blake T. Aftab and Mark S. Anderson and Joseph L. Derisi and Michael R. Wilson and Rachael J M Bashford-Rogers and Michael Platt{\'e}n and K. Christopher Garcia and Lawrence Steinman and William H. Robinson},
  journal={Nature},
  year={2022}
}
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive lymphocytes attack the myelin sheath of the central nervous system (CNS). B lymphocytes in the cerebrospinal fluid (CSF) of MS patients contribute to inflammation and secrete oligoclonal immunoglobulins1,2. Epstein-Barr virus (EBV) infection has been linked to MS epidemiologically, but its pathological role remains unclear3. Here we demonstrate high-affinity molecular mimicry between the EBV transcription factor… 
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