Clonality of cell populations in refractory anaemia using combined approach of gene loss and X-linked restriction fragment length polymorphism-methylation analyses.

@article{Abrahamson1991ClonalityOC,
  title={Clonality of cell populations in refractory anaemia using combined approach of gene loss and X-linked restriction fragment length polymorphism-methylation analyses.},
  author={G M Abrahamson and Jacqueline Boultwood and J. Patrick Madden and Steven Kelly and David Oscier and Katrina Rack and Veronica J. Buckle and J Stephen Wainscoat},
  journal={British journal of haematology},
  year={1991},
  volume={79 4},
  pages={550-5}
}
We have used X-linked restriction fragment length polymorphism (RFLP)-methylation and gene deletion analyses to investigate the nature of the progenitor cell of origin in the myelodysplastic syndromes (MDS). Gene deletion studies were performed on the granulocyte and T-lymphocyte fractions of six women with refractory anaemia (RA) and either a partial deletion of the long arm of chromosome 5 (5q-) or monosomy 7. All six showed gene loss in the granulocyte but not the T-lymphocyte fractions… CONTINUE READING

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