Clonality and molecular pathogenesis of mastocytosis.

@article{Akin2005ClonalityAM,
  title={Clonality and molecular pathogenesis of mastocytosis.},
  author={Cem Akin},
  journal={Acta haematologica},
  year={2005},
  volume={114 1},
  pages={
          61-9
        }
}
Mast cell is a hematopoietic lineage dependent on Kit signaling for growth, differentiation, and survival. Mast cells are found in excessive numbers in tissues in a heterogeneous group of disorders collectively known as mastocytosis. Last decade has witnessed important advancements in our understanding of the molecular pathology of mastocytosis. First, systemic mastocytosis has been found to be associated with activating codon 816 mutations of the c-kit gene. Second, this mutation was used as a… CONTINUE READING
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