Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization.

@article{Lffler1997ClonalityAL,
  title={Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization.},
  author={Markus L{\"o}ffler and T Bratke and Ursula Paulus and You Quan Li and Christopher S. Potten},
  journal={Journal of theoretical biology},
  year={1997},
  volume={186 1},
  pages={41-54}
}
The organization and control of stem cells is a key issue in epithelial cell biology. The small intestinal murine crypt is a useful tissue to study such problems since stem cells are known to be located at specific positions at the bottom of the crypt where they are self maintaining. Recent data suggest, that (1) the number of active stem cells in a crypt can fluctuate, (2) the immediate progeny of a single stem cell can replace other stem cells eventually leading to monoclonality and (3) the… CONTINUE READING