Clonality and field cancerization in intraductal papillary-mucinous tumors of the pancreas.

@article{Izawa2001ClonalityAF,
  title={Clonality and field cancerization in intraductal papillary-mucinous tumors of the pancreas.},
  author={Tsutomu Izawa and Takao Obara and Satoshi Tanno and Yusuke Mizukami and Nobuyuki Yanagawa and Yutaka Kohgo},
  journal={Cancer},
  year={2001},
  volume={92 7},
  pages={1807-17}
}
BACKGROUND Multiple lesions of intraductal papillary-mucinous tumor of the pancreas (IPMT) in the same pancreas often are encountered. To elucidate field (multicentric) cancerization and clonality of IPMT, clonal analyses of IPMT and its precursor lesion of ductal hyperplasia were performed. K-ras codon 12 mutations and X-chromosome inactivation of human androgen receptor gene (HUMARA) were investigated. METHODS Paraffin embedded tissue samples from the pancreata of 37 patients who underwent… CONTINUE READING
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