Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes.

@article{Mahale2008ClonalSI,
  title={Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes.},
  author={Alka M Mahale and Zahid A. Khan and Makoto Igarashi and Gouri J Nanjangud and Rui Fang Qiao and Shen Yao and Sam W. Lee and Stuart A. Aaronson},
  journal={Cancer research},
  year={2008},
  volume={68 5},
  pages={
          1417-26
        }
}
Recent evidence has implied that disruption of a limited number of defined cellular pathways is necessary and sufficient for neoplastic conversion of a variety of normal human cell types in tissue culture. We show instead that malignancy in such models results from an iterative process of clonal selection in vitro and/or in vivo. Normal human fibroblasts underwent malignant transformation after transduction with telomerase, cyclin-dependent kinase 4, dominant-negative p53, and activated Ras or… CONTINUE READING

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