Clonal selection and learning in the antibody system

@article{Rajewsky1996ClonalSA,
  title={Clonal selection and learning in the antibody system},
  author={Klaus Rajewsky},
  journal={Nature},
  year={1996},
  volume={381},
  pages={751-758}
}
Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated through somatic hypermutation. Here only mutants binding antigen with high affinity survive to become memory cells. Cells expressing autoreactive receptors are counter-selected at both stages. This stringent… 
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