Clonal regulation of the induction of macrophage-and granulocyte-inducing proteins for normal and leukemic myeloid cells.


A cloned line of myeloid leukemic cells can be induced by the alkylating agent nitrosoguanidine for two macrophage- and granulocyte-inducing (MGI) activities. One activity, MGI-I, induced the formation of macrophage and granulocyte colonies from normal myeloblasts. Another activity, MGI-2, induced differentiation of MGI+D+ myeloid leukemic cells to… (More)


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