Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL.

@article{Chan1986ClonalRA,
  title={Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL.},
  author={L. M. Chan and Andrew J.W Furley and Anthony M. Ford and D A Yardumian and Melvyn F. Greaves},
  journal={Blood},
  year={1986},
  volume={67 2},
  pages={533-6}
}
A case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor beta gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the… CONTINUE READING

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